Download PDF by Joshua Mitteldorf: Aging is a group-selected adaptation: theory, evidence, and

By Joshua Mitteldorf

Because the Nineteen Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary concept, specially within the sector of genetics. simultaneously, a technology of multilevel choice has chanced on its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic idea of senescence, wherein getting older has Read more...

summary: because the Nineties, laboratory characterization of getting older has been diverging from predictions of evolutionary thought, specifically within the zone of genetics. simultaneously, a technology of multilevel choice has stumbled on its position within the evolutionary literature. the writer means that facts warrants attention of a brand new paradigm for evolution of getting older, and proposes the demographic concept of senescence, wherein getting older has been affirmatively chosen since it degrees the demise cost over the years, assisting to stabilize inhabitants dynamics and forestall extinctions

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Extra resources for Aging is a group-selected adaptation: theory, evidence, and medical implications

Example text

C. elegans worms live longer when their capacity to sense food chemically is impaired; conversely, their lifespan is shortened even on CR if they are allowed to sense but not ingest food [44]. Calorically restricted fruit flies exposed to food-derived odors don’t live as long as the same CR flies without food odors [45]. The central role of signaling implies that there is latent capacity for extending lifespan that the body does not always deploy, but must be instructed to do so with signals that can be triggered by environmental cues.

Long-term effects of calorie or protein restriction on serum IGF-1 and IGFBP-3 concentration in humans. Aging Cell, 2008. 7(5): p. 681-7. 28. , Low methionine ingestion by rats extends life span. J. , 1993. 123(2): p. 269-274. 20 Aging is a Group-Selected Adaptation 29. , Effects of intermittent feeding upon growth and life span in rats. Gerontology, 1982. 28(4): p. 233-241. 30. , Effects of intermittent feeding upon body weight and life span in inbred mice: interaction of genotype and age. Mech.

Nature, 2012. 21. , Caloric restriction reduces age-related and all-cause mortality in rhesus monkeys. Nature communications, 2014. 5. 22. , Demography of dietary restriction and death in Drosophila. Science, 2003. 301(5640): p. 1731-1733. 23. P. B. Kirkwood, Calorie restriction and aging: a life-history analysis. Evolution Int. J. Org. Evolution, 2000. 54(3): p. 740-50. 24. , Overview of caloric restriction and aging. Mech. , 2005. 126(9): p. 913-22. 25. J. and B. Sears, Low-glycemic-load diets: impact on obesity and chronic diseases.

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